ea0032p124 | Calcium and Vitamin D metabolism | ECE2013
Viccica Giuseppe
, Borsari Simona
, Pardi Elena
, Chiavistelli Silvia
, Albertini Sonia
, Centoni Roberta
, Cetani Filomena
, Marcocci Claudio
The canonical Wnt/β-catenin pathway plays an important role in the development and patterning of bone. Dkk1 (Dickkopf1) and sclerostin are competitive soluble inhibitors of this pathway. Serum sclerostin is decreased in patients with primary hyperparathyroidism (PHPT) compared to the healthy subjects and hypoparathyroid (HypoPT) patients. No data are currently available on Dkk1 serum level in PHPT.We evaluated serum Dkk1 and sclerostin l...